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学术讲座: Cue reactivity in alcohol dependence: mechanisms and prediction of relapse
作者: 科研业务处 ║ 日期: 2016/02/26 

Speaker: Andreas Heinz, MD, PhD
      Professor of Psychiatry, Director and Chair, Department of Psychiatry and Psychotherapy,
      Charité - Universitätsmedizin Berlin, a joint institution of the Freie Universität Berlin
      and the Humboldt-Universität zu Berlin
Time:   9:00am – 11:00am
Date:   Mar 2 (Wed), 2016
Venue:     心理所南楼3层会议室
Abstract:  
Stimuli that are regularly paired with alcohol expectation or consumption can become conditioned cues that elicit craving and relapse. We studied the neurobiological correlates of alcohol cue reactivity in detoxified alcohol dependent patients and observed that increased brain activation in the medial prefrontal cortex predicts relapse, while activation in limbic areas such as the amygdale were associated with good treatment outcome. Alcohol associated and affective stimuli can interfere with independent goal-directed behaviour (Pavlovian-to-Instrumental Transfer), and indeed increased activation in the ventral striatum, a core area of the brain reward system, was increased in alcohol dependent patients with poor treatment outcome, pointing to a mechanism that explains how cues can modify complex behaviour patterns.

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