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2009年11月17日(周二)上午学术报告
日期: 2009/11/06 

报告题目:The modulation of metabotropic glutamate receptors on dendrodendritic synaptic activities in the main olfactory bulb
报告人:Hong-Wei Dong (MD. Ph.D.) 
报告时间:2009年11月17日(周二)上午9:30-11:30  
报告地点:心理所一楼报告厅

报告人简介: 

Hong-Wei Dong (MD. Ph.D.)

The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Tel: (901) 448-1226; Fax: (901) 448-7193;
Email: hdong5@utmem.edu

Education:
 
2003, M.S. Computer of Science, Webster University. St. Louis. 
1997  Ph. D., Neurobiology, Neuroscience Research Institute, Peking University, Health Science Center, China. Supervisor: Dr. Ji-Sheng Han
1992  M.D, Clinical Medicine, Hebei Zhang Jia Kou Medical College, China.
                    
Professional Experience:
 
2006- Present, Assistant Professor, Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center. Major: Neurobiology.
 
2004 - 2005, Research Scientist, Department of Anatomy and Neurobiology, University of California in Los Angeles, David Geffen School of Medicine. 
Major: Neurobiology.
 
1999 - 2003, Research Associate, Department of Anatomy and Neurobiology, Washington University in St Louis, School of Medicine,
Major: Neurobiology
 
1997 - 1998, Postdoctoral Fellow, Department of Physiology and Pharmacology, School of Medicine, St Louis University. 
Major: physiology and pharmacology.

Research Interests:
 
1)  Modulation of metabotropic receptors on the odorant transmission in the olfactory bulb. 
2)  Activation of olfactory never evoked long-term synaptic plasticity in the olfactory bulb and the mechanisms of long lasting memory associated with olfaction in advanced central cortex (limbic system). 
3)  Distribution of transient receptor potential channels in the olfactory bulb and their possible modulation on the olfaction.
4)  The relationships between olfaction and pain, emotion and endocrine function.  
5)  Investigation of the newborn dopaminergic neurons in the olfactory bulb and their potential roles in treating neurodegenerative disease. 
 
Grants:
 
" Activity-dependent plasticity of sensory synapses in the olfactory bulb", R03DC009049, NIDCD, Principle Investigator, July 2007—Jun 2010, $150,000.
"Long-term plasticity of inhibitory synapses in the main olfactory bulb", 3R03DC009049-03S1, NIDCD, Principle Investigator, Aug 2008----July 2010, $25,000. 
"Metabotropic glutamate receptors in the main olfactory bulb. 5R01DC003195, NIDCD, (PI: Matthew Ennis), co-investigator, Jan 2007--Dec 2011, $1,125,000.
 
Teaching:
 
Functional Neuroanatomy. Graduate student, University of Tennessee, HSC. 
Neuroanatomy Lab. Dental student. University of Tennessee, HSC.

Publications (CA: Corresponding Author): 
 
1.  Dong HW, Heinbockel T, Hamilton KA, Hayar A, Ennis M. Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb.  Annual New York Academy of Sciences 2009, 1170:224-238. 
2.  Dong HW CA,  Hayar A, Callaway J, Yang XH, Nai Qiang, Ennis M. mGluR1 Activation enhances non selective cation currents and rhythmic bursting in external tufted cells. Journal of Neurosci. 2009, 38:11943-11953. 
3.  Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Regulation of GABAergic inhibition of mitral cells by noradrenergic system in rat main olfactory bulb. J Neurophysiol 2009, 101: 2472-2484. 
4.  Dong HW CA, Hayar A. Ennis M. Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells. J. Neurosci. 2007, 27:5654-5663.
5.  Nai Q, Dong HW, Linster C, Ennis M. Activation of α1 and α2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Submit to J. Neurophysiol.
6.  Dong HW, Buonomano DV. A technique for repeated recordings in cortical organotypic slices.  J. Neurosci. Method 2005, 146:69-75.
7.  Dong HW, Wang QX, Valkova K, Gonchar Y, Burkhalter A. Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex. Vision Res 44: 3389-3400. 2004
8.  Dong HW, Shao ZW, Nerbonne JM, Burkhalter A.  Frequency-dependent balance of synaptic excitation and inhibition in interareal feed-forward and feedback circuits of mouse visual cortex.  J Comp Neurol. 2004,475:361-73.
9.  Dong HW CA, Wang LH, Zhang M, Han JS. Decreased Dynorphin A (1-17) in the spinal cord of spastic rats after the compressive injury. Brain Res. Bull. 2005, 67:189-195. 
10.  Zhang M, Wang XM, Zhang DB, Xu GH, Dong HW, Yu YX, Han JS. Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by m-opioid receptors. J. Mol. Neurosci. 2005, 25:21-27.
11.  Dong HW, Gan Q, Knuepfer MM.  Central CRF and adrenergic receptors mediate cocaine-induced hemodynamic response in rats.  Brain Res  2001,893:1-10.
12.  Tang NM, Dong HW, Wang XM, Tsui ZC, Han JS.  Cholecystokinin antisense RNA increases the analgesic effect induced by electroacupuncture or low dose morphine: conversion of low responder rats into high responders.  Pain  1997,71:71-80.
13.  Dong HW, Zhang W, Shi YS, Roques BP, Han JS.  The potentiation effect of RB101, enkephalin-degradation-enzyme inhibitor, on low frequency electroacupuncture analgesia.  Journal of  Chinese Pain  1996,2:33-37.
14.  Tang NM, Dong HW, Zhang LX, Han JS.  L365, 260, CCK-B receptor antagonist converse low responder rats to electroacupuncture into high responders.  Journal of Chinese Pain 1996,2:103-106.

Conference Presentation and Abstracts:
 
1.  Dong HW, Ding SY, Nai Q, Zhou FM, Zhang YH, Zhang WL, Ennis M. Detection of transient receptor potential Channel mRNA expression in the mouse main olfactory bulb. Society of Neuroscience Conference  2009, 555.16 online. 
2.  Dong HW, Ding SY, Nai Q, Zhou FM, Ennis M. Expression of transient receptor potential (TRP) channels in the mouse main olfactory bulb (MOB). AchemS 30th Annual Meeting 2009, 214.
3.  Nai Q, Dong HW, Linster, Ennis M. 1 and 2 noradrenergic receptor exert opposing effects on the excitability of rat main olfactory bulb (MOB) granule cells. AchemS 30th Annual Meeting 2009, 223.
4.  Dong HW, Nai Q, Ennis M. Activity-dependent plasticity in the strength of olfactory nerve (ON) synapses in the rat main olfactory bulb (MOB). Society for Neuroscience Conference 2008. 363.8 online
5.  Nai Q, Dong HW, Linster C, Ennis M. Activation of a1 and a2 noradrenergic receptors differentially regulates excitability of granule cells in the main olfactory bulb. Society for Neuroscience Conference 2008. 363.22
6.  Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Noradrenergic modulation of GABAergic inhibition of main olfactory bulb mitral cells.  XV International Symposium on Olfaction and Taste, 2008, 365, 
7.  Dong HW, Hayar A, Ennis M. Activation of group I mGluRs enhances rhythmic bursting and nonselective cation current in olfactory bulb external tufted cells. Society for Neuroscience Conference 2007, 277 online. 
8.  Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Activation of a1 and a2 noradrenergic receptors differentially regulates GABAergic inhibition of mitral cells in the main olfactory bulb. Society for Neuroscience Conference 2007, 504 online
9.  Dong HW, Hayar A, Ennis M. mGluR1 activation enhances nonselective cation currents and rhythmic bursting in external tufted (ET) cells. AchemS 29th Annual Meeting 2007, 292
10.  Dong HW, Hayar A, Ennis M. Activation of metabotropic glutamate receptors (mGluRs) in the glomerular layer (GL) and granule cell layer (GCL) of the olfactory bulb enhances synaptic inhibition of mitral cells. AchemS 28th Annual Meeting 2006, 238.
11.  Dong HW, Hayar A, Ennis M. Activation of metabotropic glutamate receptors (mGluRs) enhances synaptic inhibition of olfactory bulb mitral cells (MCs) via actions on GABAergic interneurons in the glomerular layer (GL) and granule cell layer (GCL). Society for Neuroscience Conference 2006, 542.5 online. 
12.  Dong HW,Buonomano DV. Transient blockade of NMDA receptors produces a long-term enhancement of inhibition and metaplasticity of LTP. Society for Neuroscience Abstracts. 2005
13.  Dong HW, Burkhalter A. Differential effects of sensory experience on inhibition in feedforward and feedback circuits between different areas of mouse visual cortex. 266.12, Society for Neruoscience, 2003. Online.
14.  Dong HW, Burkhalter A. Input-Specific spike threshold in fast-spiking interneurons connected to FF and FB pathways between different areas of mouse visual cortex. 159.1 Society for Neuroscience, 2002. Online.
15.  Dong HW, Lin M., Burkhalter A.  Experience-dependent modification of the balance of synaptic excitation and inhibition in interareal feedback circuit in developing mouse visual cortex. Soc. Neurosci. Abstr. 2001 27:1249. 
16.  Dong HW, Huang JS, Tonegawa S, Burkhalter A. Regulation of inhibition in developing interareal forward and feedback circuits in visual cortex of BDNF overexpressing mice. Soc Neurosci. Abstr. 2000, 26:855.
17.  Dong HW, Shao ZW, Burkhalter A.  Different balance of excitation and inhibition in interareal forward and feedback pathways of mouse visual cortex.  Soc. Neurosci. Abstr. 1999 25:2191. 
18.  Dong HW, Gan Q, Knuepfer MM.  Central CRF and b-adrenergic receptors mediate cocaine-induced cardiac output responses in rats.  FASEB J  1998,12:A66 (abstract).

Computer and Biological Skills:
 
Computational languages: C/C++, Matlab, SPSS, Igor, Neurolab.
Software: Skillful of using various imaging, data analysis and office tools. Photoshop7.0, illustrator CS4, Origin 8.1, CorelDraw 12.0, Minianalysis, Clamp fit 10.0 and Microsoft office 2007.
Biological Skills: Expertise in in vivo and in vitro (brain slice and acute isolated neuron) electrophysiology. Familiar with the general lab techniques in molecular biology.  
 
Professional Affiliations:
 
Member, Society of Neuroscience since 1998.
Member, Association of Chemreception Sciences since 2005.
 
Professional Services:
    Referee for
    Brain Research
    Life Science

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